Hpv and cancer review. Aspects and risks in the oropharyngeal HPV infection.


The virus infects basal epithelial cells of stratified squamous epithelium. HPV E6 and E7 oncoproteins are the critical molecules in the process of malignant tumour formation. Interacting with various cellular proteins, E6 and E7 influence fundamental cellular functions like cell cycle regulation, telomere maintenance, susceptibility to apoptosis, intercellular adhesion and regulation of immune responses.

Aspects and risks in the oropharyngeal HPV infection. Source: ORL. Author s : Vrînceanu, Daniela Abstract: Introduction.

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Squamous cell carcinomas of the head and neck are etiopathogenically associated with risk factors such as smoking and alcohol. Research over the past 10 years has provided increasing evidence for the implications of HPV 16 and 18 subtypes in the etiology of oropharyngeal cancer. Materials and method.

Cervical Cancer Staging

In this presentation, we will review the main clinical aspects of HPV infection in the oropharynx, the types of HPV associated with oropharyngeal cancer in a similar way to cervical cancer, but also the peculiarities of HPV-positive oropharyngeal cancer.

Precisely establishing the HPV etiology of an oropharyngeal malignancy may lead to changes in the oncological therapeutic protocols in oropharyngeal cancer.

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Along with the evidence related to cervical cancer, we can also discuss the possible use of large-scale anti-HPV vaccination for prevention. Copyright of ORL. However, users may print, download, or email articles for individual use. This abstract may be abridged.

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